Bruce Blumberg, Ph.D.
4103 Natural Sciences 2
Office Phone:(949) 824-8573
4351 Natural Sciences 2
Lab phone: (949) 824-6873, 3116
FAX: (949) 824-4709
Education, training, and professional experience:
(2008-present) Professor, Departments of Developmental and Cell Biology, Pharmaceutical Sciences and Biomedical Engineering, University of California, Irvine, CA.
At UCI, my laboratory continues to study the biology of nuclear hormone receptors in development, adult physiology and how both are disrupted by hormonally active compounds in the diet and environment.
(2004 - 2008) Associate Professor, Departments of Developmental and Cell Biology, Pharmaceutical Sciences and Biomedical Engineering, University of California, Irvine, CA.
(1998 - 2004) Assistant Professor, Department of Developmental and Cell Biology, University of California, Irvine, CA.
(1992-1998) Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA.
I joined Ron Evanss group at the Salk Institute as a Staff Scientist in 1992 where I spearheaded the effort to identify ligands for orphan nuclear receptors. We were successful in identifying ligands for two new receptor-mediated signaling pathways as well as previously unsuspected natural ligands for the retinoic acid receptors.
(1988-1992) Department of Biological Chemistry, UCLA Medical School, Los Angeles, CA.
In 1988, I joined the laboratory of Dr. Eddy De Robertis for a second postdoctoral fellowship. While at UCLA, I studied the molecular nature of Spemann's Organizer and isolated homeobox genes specifically expressed in the organizer. It was at this time that I became interested in intercellular signaling processes and began to study nuclear hormone receptors. I isolated six orphan nuclear receptors expressed in early Xenopus embryos and decided to focus on identifying their ligands.
(1987-1988) Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ.
My first postdoctoral training was in the laboratory of Dr. Markku Kurkinen. Here I continued my earlier studies into the structure of mouse collagen IV.
(1982-1987) Molecular Biology Institute, UCLA, Los Angeles, CA.
I did my graduate studies in the laboratory of Dr. John H. Fessler. My work was focused on the Biochemistry and Molecular Biology of the extracellular matrix, particularly collagen type IV from Drosophila and mammals.
(1973-1976) Rutgers University Camden, NJ.
As an undergraduate I first became interested in Developmental Biology while working in the laboratory of Professor Hsin-yi Lee. I received an A.B. in Biology in 1976
Campus activities - current:
Co-Director, Program in the Developmental Biology of Cancer, UCI Cancer Center (2004 - present)
Academic Senate Council on Student Experience (2006-present, Chair 2007-2008)
Network and Computing Services (NACS) advisory committee (2001 - present)
Undergraduate co-advisor for Developmental and Cell Biology Majors (2005-present)
Faculty advisor Graduate Program in Molecular Biology Genetics and Biochemistry (2006-present)
Faculty mentor Cross Cultural Center (2006-present)
Campus activities - past:
Academic Senate advisory panel for the Honors Program (2003 - 2005)
Academic Senate Council on Research, Computing, and Library Resources (2003 - 2006)
Natural Sciences II Building Advisory Committee (2000 - 2003)
BioSci machine shop committee chairman (1998 - 2004)
BioSci web site committee (1999 - 2000)
Biomedical engineering undergraduate affairs committee (2001 - 2002)
BioSci Dean's advisory committee for technology transfer (2000 - 2006)
Biomedical engineering facilities committee (1999 - 2000)
Executive committee of the faculty (2000 -2001 )
BioSci Computing committee (2004 - 2006)
BioSci Undergraduate Cabinet (2004 - 2007)
U. S. Patents:
Mouse peroxisome proliferator-activated receptor gamma US 5,861,274
Human peroxisome proliferator-activated receptor gamma compositions and methods - US 6,200,802, US 6,815,168, US 7,250,273
High throughput functional screening of cDNAs US 6,274,321
Method, polypeptides, nucleotide sequence of XOR-6 (BXR), a vitamin D-like receptor from Xenopus - US 6,391,847
Steroid-activated nuclear receptors and uses therefore (SXR) - US 6,756,491, US 6,809,178, US 7,214,482
Transgenic mice expressing a human SXR receptor polypeptide - US 6,984,773
Novel GAL4 chimeric receptors and uses therefor pending (in prosecution)
Honors and awards:
Invited Plenary Lecturer, International Workshop on the Latest Concepts in Developmental Biology, Los Cocos, Cordoba, Argentina (2006)
Invited Plenary Lecturer, "International Conference on the Promising Next Generation Technology of Toxicogenomics in Drug & Food Safety and Environmental Human Health" - 2nd annual meeting of the Korean Society of Toxicogenomics and Toxicoproteomics, Seoul, Korea (2005)
Invited Keynote Speaker, 8th Vitamin K and Bone Meeting, Tokyo, Japan (2005)
Invited Speaker and Special U.S. Delegate to the Ministry of Environment, Japan, 7th International Symposium on Environmental Endocrine Disrupters, Nagoya, Japan (2004)
Invited U.S. Delegate, OECD/IPCS Workshop on Toxicogenomics, Kyoto, Japan (2004)
Invited Special Lecture, 22nd Annual Meeting of the Japanese Society for Bone and Mineral Research, Osaka, Japan (2004)
Postdoctoral Scholar of the National Institutes of Health (1989-1992)
Postdoctoral Scholar of the Lucille P. Markey Charitable Trust (1988-1991)
Recipient USPHS Tumor and Cell Biology Training Grant (1983-1986)
Elected member of Athenaeum Honor Society of Rutgers University (1976)
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