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Kirchner, S., Kieu, T., Chow, C. Casey, S.C. and Blumberg, B. (2010). Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Molec. Endocrinol., 24, 526-539. reprint in PDF format
Grün, F., and Blumberg, B. (2009) The case for obesogens. Molec. Endocrinol., 23, 1127-1134. reprint in PDF format
Grün, F., and Blumberg, B. (2009) Endocrine disrupters as obesogens.Molecular and Cellular Endocrinology, 304, 19-29. reprint in PDF format
Zhou, C., Verma, S., Blumberg, B. (2009) The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl Recept Signal., 7, e001. reprint in PDF format
Verma, S., Tabb, M.M., and Blumberg, B. (2009) Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. BMC Cancer 9:3. reprint in PDF format
Milnes, M.R., Garcia, A., Grossman, E., Grun, F., Shiotsugu, J., Tabb, M.M., Kawashima, Y., Katsu, Y., Watanabe, H., Iguchi, T., and Blumberg, B. (2008) Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and its orthologs in laboratory, toxicological and genome model species. Environ. Health. Perspect., 116, 880-885. reprint in PDF format
Iguchi, T., Watanabe, H., Ohta, Y., and Blumberg, B. (2008) Developmental effects: oestrogen induced vaginal changes and organotin induced adipogenesis. International Journal of Andrology, 31, 263-268. reprint in PDF format
Ichikawa, T., Horie-Inoue, K., Ikeda, K., Blumberg, B., and Inoue, S., (2007) Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J. Molec. Endocrinol., 39, 239-247. reprint in PDF format
Grün, F., and Blumberg, B. (2007) Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Reviews in Endocrinology and Metabolism, 8, 161-171. reprint in PDF format
Kumagai, J., Fujimura, T., Takahashi, S., Urano, T., Ogushi, T., Horie-Inoue, K., Ouchi, Y., Kitamura, T., Muramatsu, M., Blumberg, B. & Inoue, S. (2007). Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer. The Prostate 67, 1029-37. reprint in PDF format
Iguchi, T., Katsu, Y., Horiguchi, T., Watanabe, H., Blumberg, B. and Ohta, Y. (2007) Endocrine disrupting organotin comounds are potent inducers of imposex in gastropods and adipogenesis in vertebrates. Mol. Cell. Toxicol., 3, 1-10, 2007. reprint in PDF format
Zhou, C., Poulton, E. J., Grun, F., Bammler, T. K., Blumberg, B., Thummel, K. E., Eaton, D. L. (2007) The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol, 71, 220-229. reprint in PDF format
Mensah-Osman, E. J., Thomas, D. G., Tabb, M. M., Larios, J. M., Hughes, D. P., Giordano, T. J., Lizyness, M. L., Rae, J. M., Blumberg, B., Hollenberg, P. F.; Baker, L. H. (2007) Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer, 109, 957-965. reprint in PDF format
Grün, F., Watanabe, H., Zamanian, Z., Maeda, L., Arima, K., Chubacha, R., Gardiner, D.M., Iguchi, T., Kanno, J., and Blumberg, B. (2006) Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol., 20, 2141-2155. reprint in PDF format
Ichikawa, T., Horie-Inoue, K., Blumberg, B., and Inoue, S. (2006) Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells. J. Biol. Chem., 281, 16927-16934. reprint in PDF format
Zhou, C. Assem, M., Tay, J.C., Watkins, P.B., Blumberg, B., Schuetz, E.G., and Thummel, K.E. (2006) Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J. Clin. Invest. 116, 1703-1712. reprint in PDF format
Zhou C, Tabb MM, Nelson EL, Grun F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg, B. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J Clin Invest. 2006;116(8):2280-9. PMCID: 1501109. reprint in PDF format
Grün, F., and Blumberg, B. (2006) Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology, 147, S50-S55. reprint in PDF format
Tabb, M.M., and Blumberg, B. (2006) New modes of action for endocrine-disrupting chemicals. Mol. Endocrinol. 20, 475-482. reprint in PDF format
Gunderson, M.P., Kohno, S., Blumberg, B., Iguchi, T., and Guillette, L.J. Jr. (2006) Induction of an alligator CYP3A gene by toxaphene and dexamethasone. Aquatic Toxicology, 78, 272-283. reprint in PDF format
Miki Y., Suzuki, T., Kitada, K., Yabuki, N., Shibuya, R., Moriya, T., Ishida, T., Ohuchi, N., Blumberg, B., and Sasano, H. (2006) Expression of the Steroid and Xenobiotic Receptor and Its Possible Target Gene, Organic Anion Transporting Polypeptide-A, in Human Breast Carcinoma. Cancer Research 66, 535-542. reprint in PDF format
Miki Y., Suzuki T., Tazawa C., Blumberg B., Sasano H. (2005) Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol. 231, 75-85. reprint in PDF format
Arima, K., Shiotsugu, J., Niu, R., Khandpur, R., Martinez, M., Shin, Y., Koide, T., Cho, K.W.Y., Kitayama, A., Ueno, N., Chandraratna, R.A.S., and Blumberg, B. (2005) Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays. Dev. Dyn., 232, 414-431. reprint in PDF format
Zhou, C., Tabb, M.M., Sadatrafiei, A., Grün, F., Sun, A., and Blumberg, B. (2004) Hyperforin, the Active Component of St. John's Wort, Induces IL-8 Gene Expression in Human Intestinal Epithelial Cells via a MAPK-dependent, NF-kB-independent Pathway, J. Clin. Immunol., 24, 623-636. reprint in PDF format
Zhou, C., Tabb, M.M., Sadatrafiei, A., Grün, F., and Blumberg, B. (2004) Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metabolism and Disposition 32, 1075-1082. reprint in PDF format
Shiotsugu, J., Katsuyama, Y., Arima, K., Baxter, A., Koide, T., Song, J., Chandraratna, R.A.S., and Blumberg, B. (2004) Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development, 131, 2653-2667. reprint in PDF format
Tabb, M.M., Kholodovych, V., Grün, F., Zhou, C., Welsh, W.J., and Blumberg, B. (2004) Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the Steroid and Xenobiotic Receptor (SXR). Environmental Health Perspectives, 112, 163-169. reprint in PDF format
Tabb, M.M., Sun, A., Errandi, J.L., Zhou, C., Grün, F., Romero, K., Inoue, S., and Blumberg, B. (2003) Vitamin K2 regulation of bone homeostasis is mediated by the orphan receptor, SXR. J. Biol. Chem. 278, 43919-43927. reprint in PDF format
Gardiner, D.M., Ndayibagira, A., Grün, F., and Blumberg, B. (2003) Deformed Frogs and Environmental Retinoids. Pure and Applied Chemistry 75, 2264-2273. reprint in PDF format
Peng, J., Riggs, B.L., Ogino, H., and Blumberg, B. (2003) Construction of a Set of Full-Length Enriched cDNA Libraries as Genomics Tools for Xenopus Tropicalis Research Current Genomics, 4, 635-644.. reprint in PDF format
Grün, F., and Blumberg, B. (2003). Use of Xenopus as a tool for orphan nuclear receptor characterization. Methods in Enzymology 364, 3-24. reprint in PDF format
Weston, A.D., Blumberg, B., and Underhill, T.M. (2003). Active repression by unliganded retinoid receptors in development: less is sometimes more. J. Cell Biol., 161, 223-228. reprint in PDF format
Zhou, C. and Blumberg, B. (2003) Overlapping Gene Structure of Human VLCAD and DLG4. Gene 305, 161-166. reprint in PDF format
Tabb, M.M., Zhou, C., and Blumberg, B. (2003) SXR and the Xenobiotic Response. In Toxicogenomics (T. Inoue, W.D. Pennie, Eds. Springer Verlag, Tokyo). reprint in PDF format
Grün, F., Venkatesan, R.N., Tabb, M.M., Zhou, C., Cao, J., Hemmati, D., and Blumberg, B. (2002). Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J. Biol. Chem. 277, 43691-43697. reprint in PDF format
Gabriel, W., Blumberg, B., Sutton, S., Place, A.R., and Lance, V.A. (2001) Alligator aromatase cDNA sequence and its expression in embryos at male and female incubation temperatures. J. Exp. Zool., 290, 439-448. reprint in PDF format
Blumberg, B. (2001) Identification of Nuclear Hormone Receptor Homologs by Screening Libraries with Highly Degenerate Oligonucleotide Probes, Methods in Molecular Biology, 176, 119-129. reprint in PDF format
Koide, T., Downes, M., Chandraratna, R.A.S., Blumberg, B*. and Umesono, K. (2001) Active repression of RAR signaling is required for head formation. Genes Dev., 15, 2111-2121. reprint in PDF format *corresponding and senior author
Xie, W., Barwick, J. L., Simon, C. M., Pierce, A., Safe, S., Blumberg, B., Guzelian, P. S., and Evans, R. M. (2000). Reciprocal activation of target CYP genes by nuclear receptors SXR/PXR and CAR. Genes Dev., 14, 3014-3023. reprint in PDF format
Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., and Evans, R. M. (2000). Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406, 435-439. reprint in PDF format
Tsukui, T. Capdevila, J., Yonei Tamura, S., Ruiz-Lozano, P., Rodriguez-Esteban,C., Tamura, K., Magallon, J., Chandraratna, R.A.S., Chien, K., Evans, R.M., Blumberg, B., and Izpisúa Belmonte, J.C. (1999). Multiple Left-right Asymmetry Defects in Shh -/- Mutant Mice Unveil a Convergence of the Shh and Retinoic Acid Pathways in the Control of Lefty-1. Proc. Natl. Acad. Sci. (U.S.A.), 96, 11376-11381. reprint in PDF format
Blumberg, B., and Izpisúa Belmonte, J. C. (1999) Subtractive hybridization and cDNA library construction. Methods in Molecular Biology 97, 555-574. reprint in PDF format
Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C., Ong, E.S., and Evans, R.M. (1998) SXR, a novel steroid and xenobiotic-activated nuclear hormone receptor. Genes Dev. 12, 3195-3205. reprint in PDF format
Blumberg, B. and Evans, R.M. (1998) Orphan nuclear receptors - New ligands and new possibilities. Genes Dev. 12, 3149-3155. reprint in PDF format
Ryan, A.K., Blumberg, B.*, Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Pena, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., and Izpizua-Belmonte, J.C. (1998) Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature. 394, 545-552. reprint in PDF format *joint first authorship
Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A.G., Moreno, T.A., Umesono, K., Perlmann, T., De Robertis, E.M., and Evans, R.M. (1998) BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev., 12, 1269-1277. reprint in PDF format
Pillemer, G., Epstein, M., Blumberg, B., Yisraeli, J.K., De Robertis, E.M., Steinbeisser, H., and Fainsod, A. (1997). Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech. Dev. 71, 196-196. reprint in PDF format
Blumberg, B. (1997). An essential role for retinoid signaling in anteroposterior neural specification and neuronal differentiation. Seminars Cell Dev. Biol. 8, 417-428. reprint in PDF format
Bellefroid, E., Bourguignon, C., Bouwmeester, T., Rausch, O., Blumberg, B., Pieler, T. (1997) Transcription regulation and alternative splicing of an early zygotic gene encoding two structurally distinct zinc finger proteins in Xenopus laevis. Mech. Dev. 63, 99-108. reprint in PDF format
Blumberg, B., Bolado, J., Moreno, T.A., Kintner, C., Evans, R.M., and Papalopulu, N. (1997) An essential role for retinoid signaling in anteroposterior neural patterning, Development 124, 373-379. reprint in PDF format
Mullen, L.M., Bryant, S.V., Torok, M.A., Blumberg, B., and Gardiner, D.M. (1996) Nerve dependency of regeneration: the role of Distal-less and FGF signaling in amphibian limb regeneration. Development 122, 3487-3497. reprint in PDF format
Ackhar, C., Derguini, F., Blumberg, B., Langston, A., Levin, A., Speck, J., Evans, R.M., Bolado, J., Jr., Buck, J. and Gudas, L.J. (1996) 4-oxo-Retinol, a natural ligand and transactivator of the retinoic acid receptors. Proc. Natl. Acad. Sci. (USA) 93, 4891-4896. reprint in PDF format
Blumberg, B., Bolado, J., Derguini, F., Craig, A., Moreno, T.A., Chakravarti, D., Heyman, R.A., Buck, J., and Evans, R.M. (1996) Identification of novel retinoic acid receptor ligands from Xenopus. Proc. Natl. Acad. Sci. (USA) 93, 4873-4890. reprint in PDF format
Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R.M. (1995) The nuclear receptor superfamily: The second decade. Cell 83, 835-839. reprint in PDF format
Hawlet, S., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M., Watabe, T., Blumberg, B., and Cho, K.W.Y. (1995) Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev. 9, 2923-2935.
Greene, M.E., Blumberg, B., McBride, O.W., Yi, H.F., Kronquist, K., Kwan, K., Hsieh, L., Greene, G., and Nimer, S.D. (1995) Isolation of the human peroxisome proliferator activated receptor g cDNA: Expression in hematopoietic cells and chromosomal mapping. Gene Expression 4, 281-299.
Gardiner, D.M., Blumberg, B., Komine, Y., and Bryant, S.V. (1995) Regulation of HoxA expression in developing and regenerating axolotl limbs. Development 121, 1731-1741. reprint in PDF format
Nelson, R.E., Fessler, L.I., Takagi, Y., Blumberg, B., Keene, D.R., Olson, P.F., Parker, C.G., and Fessler, J.H. (1994) Peroxidasin: a novel enzyme-matrix protein of Drosophila development. EMBO J. 13, 3438-3447.
Forman, B.M., Chen, J., Blumberg, B., Kliewer, S.A., Henshaw, R., Ong, E.S., and Evans, R.M. (1994) Cross-talk among ROR a1 and the Rev-erb family of orphan nuclear receptors. Mol. Endocrinol. 8, 1253-1261. reprint in PDF format
Kliewer, S.A., Forman, B., Blumberg, B., Ong, E.S., Borgmeyer, U., Mangelsdorf, D.J., Umesono, K., and Evans, R.M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. (USA) 91, 7355- 7359. reprint in PDF format
Gardiner D.M., Blumberg, B., Bryant, S.V. (1993) Expression of homeobox genes in limb regeneration. Progress in Clinical and Biological Research, 383A, 31-40.
Gont, L.K., Steinbeisser, H., Blumberg, B., and De Robertis, E.M. (1993) Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development 119, 991-1004. reprint in PDF format
Blum, M., Gaunt, S.J., Cho, K.W., Steinbeisser, H., Blumberg, B., Bittner, D., and De Robertis, E.M. (1992) Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106. reprint in PDF format
Blumberg, B., Mangelsdorf, D.J., Dyck, J., Bittner, D.A., Evans, R.M., and De Robertis, E.M. (1992) Multiple retinoid-responsive receptors in a single cell: families of RXRs and RARs in the Xenopus egg. Proc. Natl. Acad. Sci. (U.S.A.) 89, 2321-2325. reprint in PDF format
Cho, K.W.Y., Blumberg, B., and De Robertis, E.M. (1992) Cooperation between mesoderm-inducing growth factors and retinoic acid in Xenopus axis formation. (1991) Seminars in Developmental Biology 2, 393-403.
Cho, K.W.Y., Blumberg, B., Steinbeisser, H., and De Robertis, E.M. (1991) Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120. reprint in PDF format
Blumberg, B., Wright, C.V.E., De Robertis, E.M., and Cho, K.W.Y. (1991) Organizer- specific homeobox genes from Xenopus laevis embryos. Science 253, 194-196. reprint in PDF format
Saus, J., Quinones, S., MacKrell, A., Blumberg, B., Muthukumaran, G., Pihlajaniemi, T., and Kurkinen, M. (1989) The complete primary structure of mouse a2(IV) collagen: Alignment with mouse a1(IV) collagen. J. Biol. Chem. 264, 6318-6324. reprint in PDF format
Muthukumaran, G., Blumberg, B., and Kurkinen, M. (1989) The complete primary structure for the a1-chain of mouse collagen IV: Differential evolution of collagen IV domains. J. Biol. Chem. 264, 6310-6317. reprint in PDF format
Blumberg, B., MacKrell, A.J., and Fessler, J.H. (1988) Drosophila basement membrane procollagen a1(IV): II. Complete cDNA sequence, genomic structure and general implications for supramolecular assemblies. J. Biol. Chem. 263, 18328-18337. reprint in PDF format
MacKrell, A.J., Blumberg, B., Haynes, S., and Fessler, J.H. (1988) The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta-subunits. Proc. Natl. Acad. Sci. (U.S.A.) 85, 2633-2637. reprint in PDF format
Blumberg, B., MacKrell, A.J., Olson, P.F., Kurkinen, M., Monson, J.M., Natzle, J.E., and Fessler, J.H. (1987). Basement membrane procollagen IV and its specialized carboxyl domain are conserved in Drosophila, mouse, and human. J. Biol. Chem. 262, 5947-5950. reprint in PDF format
Kurkinen, M., Condon, M.R., Blumberg, B., Barlow, D., Quinones, S., Saus, J., and Pihlajaniemi, T. (1987). Extensive homology between the carboxyl-terminal peptides of mouse a1(IV) and a2(IV) collagen. J. Biol. Chem. 262, 8496-8499. reprint in PDF format
Blumberg, B., Fessler, L.I., Kurkinen, M., and Fessler, J.H. (1986). Biosynthesis and supramolecular assembly of procollagen IV in neonatal lung. J. Cell Biol. 103, 1711-1719. reprint in PDF format.
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